2011

Developing textures with DC Polyols

The authors propose different methodologies for assessing the feelings of brittleness, crunchiness and melting in the mouth upon chewing tablets formulated with polyols.

The development of solid dosage forms that can be chewed or easily dispersed in the mouth is particularly attractive for the paediatric and geriatric markets.  A key challenge for the final patient’s acceptance is in the design of tablets having an appealing texture, as well as an acceptable taste and mouthfeel. The selection of excipients is critical in achieving a tablet’s disintegration in the oral cavity, a pleasant mouthfeel, and robust tablets that can withstand processing and transportation.

Our DC polyols range displays a palette of different textures as a result of their inherent physicochemical properties, such as enthalpy of dissolution and crytal shapes. For instance, Xylitol exhibits a cooling effect upon dissolution in the mouth and tablets containing maltitol provide a ‘crunchy’ sensation when chewed.

The purpose of this study was to propose different methodologies for assessing the feelings of brittleness, crunchiness and melting in the mouth upon chewing tablets formulated with polyols.

  

Reproduced courtesy of Pharma magazine


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