2011

Evaluation of a Novel Modified Starch Polymer as a Ready to Use Excipient

lycoat® Magnifying Glass

This poster presents an evaluation of LYCOAT® RS720 and their advantages over the Oral Disintegrating Film market.

 

Carmen POPESCU(1), Michael MOORE(1), Alain FRANCOIS(2), Bo ZHOU(3), María Elisa LUQUE(3), Pierre KOCH(3), Delphine DAMOUR(2), Liuming ZHOU(1), Qi FANG(4), Philippe LEFEVRE(2) and Rodolfo PINAL(3)

(1)Roquette America Inc., Geneva, IL,
(2) Roquette Frères, Lestrem, France,
(3) Purdue University, West Lafayette, IN,
(4) Banner Pharmacaps Inc, High Point, NC


INTRODUCTION

•In recent years ODF became a very popular drug delivery system due to the fact that it can deliver the drug directly to the systemic circulation (avoiding the first pass metabolism).

•It enhances drug efficacy by lowering the dose and improving the onset of action and consequently patient compliance.

•To get the required rheological properties several hydrosoluble polymers and plasticizers are generally selected. Using only one polymer, a non-GMO pregelatinized hydroxypropyl pea starch, Lycoat RS720 we obtained the desired mechanical, rheological, and functional properties.

• Using the film casting technique (at room temperature) we obtained an ODF construct having good drug uniformity and dissolution performance.